(1S,2R)-Alicapistat
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(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)[1]. (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM[2].
- CAS number: 2221010-57-5
- Purity: 98.0
- Formula: C25H27N3O4
- Solubility: 10 mM in DMSO
- SMILES: O=C1N([C@H](CC1)C(N[C@H](C(C(NC2CC2)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4
- Molecular Weight: 433.50
- Applications: Neuroscience-Neurodegeneration
- -20°C, 3 years
- 4°C, 2 years (Powder)
For research use only. Not to be used for human or animal treatment or consumption.
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