(1S,2R)-Alicapistat
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(1S,2R)-Alicapistat
- SMILES: C(N1[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(C(NC3CC3)=O)=O)=O)CCC1=O)C4=CC=CC=C4
- Formula: C25H27N3O4
- Purity: 0.9805
- CAS#: 2221010-57-5
- Molecular Weight: 433.5
- Bioactivity: (1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 with the potential application of Alzheimer's disease (AD) [1]. (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC 50 value of 395 nM [2].
For research use only.
