Human Relaxin-3 Recombinant Protein
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Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.
- Gene name: Relaxin-3
- Host: E. coli
- Label: None
- Applications: Data not available.
- Species Reactivity/Origin species: Human
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Endotoxin levels: < 0.1 ng/µg of protein (<1EU/µg)
- Additives/Stabilizer: None
- Form: lyophilized
- MW: 5.5 kDa
- Length (aa): 51
- Protein Sequence: A-chain: DVLAGLSSS CCKWGCSKSE ISSLC
- B-chain: RAAPYGVRL CGREFIRAVI FTCGGSRW
- NCBI GeneID: 117579
- Accession Number Protein: NP_543140.1
- Accession Numberm RNA: NM_080864
- Uniprot: Q8WXF3
- Chromosomal location: 19p13.2
For research use only.
