Anti-Mouse Lyve-1 Antibody
€ Preis anfragen
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
- Gene name: Lyve-1
- Host: Rabbit
- Label: None
- Applications: WB, IHC (C), IF, FC
- Western Blot: use at 2-5 µg/ml
- FACS: use at 3-10 µg/ml
- IF/IHC: applicable with cryo-sections.
- Species Reactivity/Origin species: Mouse
- Antigen: Recombinant mouse soluble Lyve-1 (RT#S01-026)
- Purification method: Antigen-affinity purified
- Reconstitution Buffer: water
- Buffer: PBS
- Additives/Stabilizer: None
- Form: lyophilized
- Storage: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
- Reconstitution tips: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- NCBI GeneID: 114332
- Accession Number Protein: NP_444477
- Accession Numberm RNA: NM_053247
- Uniprot: Q8BHC0
- Chromosomal location: 7
- 7F2
For research use only.
