Anti-Human IL-6 Antibody
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IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
- Gene name: IL-6
- Host: Mouse
- Label: None
- Isotype: IgG2
- Applications: ELISA, WB
- Species Reactivity/Origin species: Human
- Antigen: Recombinant Human IL-6
- Purification method: Protein A chromatography
- Reconstitution Buffer: water
- Buffer: PBS
- Additives/Stabilizer: None
- Form: lyophilized from PBS
- Storage: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
- Reconstitution tips: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- NCBI GeneID: 3569
- Accession Number Protein: NP_000579
- Accession Numberm RNA: NM_000600
- Uniprot: P05231
- Chromosomal location: 7p21
For research use only.
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