Anti-Human Eotaxin-2 Antibody
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Eotaxin2, also named MPIF-2 and Ckβ6, is a CC chemokine that is designated CCL24. Eotaxin2 cDNA encodes a 10.5 kDa, 119 amino acid residue precursor protein with a 26 aa residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N-glycosylation site. C-terminally truncated variants with 78, 73, 75 and 76 residues have also been described. Eotaxin 2 shares 40%, 42% and 39% amino acid sequence identity with other CC chemokines CCL7/MCP3, CCL3/MIP1α, and CCL11/Eotaxin, respectively. Eotaxin2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant Eotaxin2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes, but not monocytes or activated T lymphocytes. Eotaxin2 also suppresses colony formation by high proliferative multipotential hematopoietic progenitors. On eosinophils, the effects of Eotaxin2, Eotaxin and CCL13/MCP4 are mediated by the receptor CCR3.
- Gene name: Eotaxin-2
- Host: Mouse
- Label: None
- Isotype: IgG1, kappa
- Applications: ELISA, WB, IHC (P)
- Species Reactivity/Origin species: Human
- Antigen: Recombinant Human Eotaxin-2 (CCL24)
- Purification method: Protein A chromatography
- Reconstitution Buffer: water
- Buffer: PBS
- Additives/Stabilizer: None
- Form: lyophilized from PBS
- Storage: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
- Reconstitution tips: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
- NCBI GeneID: 6369
- Accession Number Protein: NP_002982.2
- Accession Numberm RNA: NM_002991
- Uniprot: O00175
- Chromosomal location: 7q11.23
For research use only.
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