Sunitinib-d10
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Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].
- CAS number: 1126721-82-1
- Purity: 99.89
- Formula: C22H17D10FN4O2
- Solubility: 10 mM in DMSO
- SMILES: O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H]
- Molecular Weight: 408.54
- Applications: Cancer-Kinase/protease
- -20°C, 3 years
- 4°C, 2 years (Powder)
For research use only. Not to be used for human or animal treatment or consumption.
