Peretinoin
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Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
- CAS number: 81485-25-8
- Purity: 99.79
- Formula: C20H30O2
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- SMILES: C/C(C)=C/CC/C(C)=C/CC/C(C)=C/C=C/C(C)=C/C(O)=O
- Molecular Weight: 302.45
- Applications: Cancer-Kinase/protease
-20°C (Powder, protect from light, stored under nitrogen)
