MK-2206 (dihydrochloride)
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MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active allosteric AKT inhibitor with IC50s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy[1][2].
- CAS number: 1032350-13-2
- Purity: 99.99
- Formula: C25H23Cl2N5O
- Solubility: DMSO : 12.5 mg/mL (ultrasonic
- warming
- heat to 60°C)|H2O : 3.57 mg/mL (ultrasonic
- warming
- heat to 60°C)
- SMILES: O=C1N2C(C3=CC(C4=CC=CC=C4)=C(N=C3C=C2)C5=CC=C(C6(N)CCC6)C=C5)=NN1.Cl.Cl
- Molecular Weight: 480.39
- Applications: Cancer-Kinase/protease
4°C (Powder, sealed storage, away from moisture)
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