HCV-371
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HCV-371
- SMILES: N#CC1=CC=C(C)C2=C1C3=C([C@](OCC3)(CC(O)=O)CCC)N2
- Formula: C18H20N2O3
- Purity: 0.98
- CAS#: 675184-27-7
- Molecular Weight: 312.37
- Bioactivity: HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerases). This indicates that it is specific for HCV polymerase. Fluorescence binding studies have shown that HCV-371 binds to NS5b at an apparent dissociation constant of 150 nM, resulting in high selectivity and non-cytotoxicity in antiviral tests.
For research use only.
