GRPR antagonist-1
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- Purity: 0.98
- Molecular Weight: 558.59
- Bioactivity: GRPR antagonist-1 is a potent gastrin releasing peptide receptor ( GRPR ) antagonist, having the cytotoxicity against certain cancer cells ( IC 50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis. Anticancer activity [1].