CHIKV-IN-2
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- SMILES: CC(C)(c(cc1)ccc1NC(c(cc(CCCCC1)c1c1)c1OC)=O)C#N
- Formula: C23H26N2O2
- Purity: 0.9867
- CAS#: 2361289-44-1
- Molecular Weight: 362.46
- Bioactivity: CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools. Therefore, CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability[1].