CCT251545 analogue, Compound 51
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CCT251545 analogue, Compound 51
- SMILES: NC1=C2C(N=C(C(N3CC(OC)C3)=O)C=C2)=C(C4=CC=C(C5=CN(C)N=C5)C=C4)C=N1
- Formula: C23H22N6O2
- Purity: 0.98
- CAS#: T22633
- Molecular Weight: 414.46
- Bioactivity: CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastric and colorectal cancers through the activation of WNT signaling.
For research use only.
