Famotidine
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Famotidine is a histamine H2 receptor antagonist. It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex). Famotidine blocks the action of histamine in the parietal cells, ultimately blocking acid secretion in the stomach. It inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6µM) and suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400µg/kg, respectively). Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD) and heartburn and it decreases the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs). Potential inhibitor of the viral enzyme papain-like protease (PLpro), important for SARS-CoV-2 replication and being tested in COVID-19 clinical trials.
- Predicted Molecular Weight: 337,5
- Physical State: Lyophilized
- Purity: greater than or equal to 98% (HPLC)
- Formula: C8H15N7O2S3
- Source: N/A
- CAS: 76824-35-6
- Soluble in: Soluble in DMSO (30mg/ml) or DMF (25mg/ml).
- InChi Key: XUFQPHANEAPEMJ-UHFFFAOYSA-N
- Smiles: N/C(N)=N/C1=NC(CSCC/C(N)=N/S(=O)(N)=O)=CS1
- RTECS: N/A
- Identity: Determined by 1H-NMR.
- Merk: N/A
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Protect from moisture. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
For Research Use Only
