Darunavir
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Darunavir is a highly potent HIV protease inhibitor (IC50=3-6nM, depending on laboratory HIV-1 strain), an antiretroviral medication used to treat and prevent HIV/AIDS. Darunavir is a second generation HIV-1 protease inhibitor that inhibits replication of various laboratory strains and clinical isolates of HIV-1, including those resistant to first generation protease inhibitors. It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations. Formulations containing darunavir have been used in combination therapy for the treatment of HIV. The Darunavir ethanolate (Prod. No. AG-CR1-3724) formulation has some stability advantages compared to the free base Darunavir. Shown in a SARS-CoV-2 protease structure model study to potentially bind and inhibit the papain-like viral protease (PLVP) of SARS-CoV-2, responsible for COVID-19.
- Predicted Molecular Weight: 547,7
- Physical State: Lyophilized
- Purity: greater than or equal to 98% (HPLC)
- Formula: C27H37N3O7S
- Source: N/A
- CAS: 206361-99-1
- Soluble in: Soluble in DMSO (30mg/ml). Very slightly soluble in water (~0.15mg/ml).
- InChi Key: CJBJHOAVZSMMDJ-HEXNFIEUSA-N
- Smiles: NC1=CC=C(S(=O)(N(C[C@@H](O)[C@H](CC2=CC=CC=C2)NC(O[C@H]3CO[C@]4([H])[C@@]3([H])CCO4)=O)CC(C)C)=O)C=C1
- RTECS: N/A
- Identity: N/A
- Merk: N/A
Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
For Research Use Only
