Vonoprazan
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Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori[1][2][3].
- CAS number: 881681-00-1
- Purity: 99.89
- Formula: C17H16FN3O2S
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- SMILES: O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O
- Molecular Weight: 345.39
- -20°C, 3 years
- 4°C, 2 years (Powder)
