Vonoprazan (hydrochloride)
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Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori[1][2][3].
- CAS number: 1957202-44-6
- Formula: C17H17ClFN3O2S
- Solubility: 10 mM in DMSO
- SMILES: O=S(C1=CC=CN=C1)(N2C=C(CNC)C=C2C3=C(F)C=CC=C3)=O.Cl
- Molecular Weight: 381.85
- Applications: Metabolism-sugar/lipid metabolism
For research use only. Not to be used for human or animal treatment or consumption.
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