Tomivosertib
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Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance[2].
- CAS number: 1849590-01-7
- Purity: 99.92
- Formula: C17H20N6O2
- Solubility: DMSO : 4.35 mg/mL (ultrasonic)
- SMILES: O=C(C1=C(C)C=C(NC2=NC=NC(N)=C2)C(N13)=O)NC43CCCCC4
- Molecular Weight: 340.38
- Applications: Cancer-Kinase/protease
- -20°C, 3 years
- 4°C, 2 years (Powder)
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