SIS3 (free base)
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SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1].
- CAS number: 521985-36-4
- Purity: 98.11
- Formula: C28H27N3O3
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- SMILES: O=C(/C=C/C1=C(N(C2=NC=CC=C21)C)C3=CC=CC=C3)N4CC5=C(CC4)C=C(C(OC)=C5)OC
- Molecular Weight: 453.53
- Applications: COVID-19-immunoregulation
- -20°C, 3 years
- 4°C, 2 years (Powder)
For research use only. Not to be used for human or animal treatment or consumption.