Reverse transcriptase-IN-4
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Reverse transcriptase-IN-4 (compound F10) is a potent and selective non-nucleoside reverse transcriptase (NNRT) inhibitor with an EC50 value of 0.053 μM for wild-type HIV-1 and an EC50 value of 0.26 μM for HIV-1 mutant E138K[1]. Reverse transcriptase-IN-4 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
- Formula: C17H21N5OS
- Solubility: 10 mM in DMSO
- SMILES: CC1=CC(C)=CC(C(C2=C(C(NC(SC(C)C)=N2)=O)C)N=[N+]=[N-])=C1
- Molecular Weight: 343.45
- Applications: COVID-19-anti-virus
For research use only. Not to be used for human or animal treatment or consumption.
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