R406 (free base)
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R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation[1]. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
- CAS number: 841290-80-0
- Purity: 99.80
- Formula: C22H23FN6O5
- Solubility: DMSO : 25 mg/mL (ultrasonic
- warming
- heat to 60°C)
- SMILES: COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC
- Molecular Weight: 470.45
- Applications: COVID-19-immunoregulation
- -20°C, 3 years
- 4°C, 2 years (Powder)
