Nec-3a
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Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].
- CAS number: 1504558-72-8
- Formula: C21H18F4N2O4
- Solubility: 10 mM in DMSO
- SMILES: COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1
- Molecular Weight: 438.37
For research use only. Not to be used for human or animal treatment or consumption.
