Minocycline (hydrochloride)
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Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect[1][2][3][4][5][6][7].
- CAS number: 13614-98-7
- Purity: 99.79
- Formula: C23H28ClN3O7
- Solubility: DMSO : 19.23 mg/mL (ultrasonic)|H2O : 9.09 mg/mL (ultrasonic)
- SMILES: OC1=C(C(N)=O)C([C@@]2(O)C(O)=C3C(C4=C(O)C=CC(N(C)C)=C4C[C@@]3([H])C[C@@]2([H])[C@@H]1N(C)C)=O)=O.Cl
- Molecular Weight: 493.94
- Applications: COVID-19-immunoregulation
4°C (Powder, sealed storage, away from moisture)
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