MA242 (free base)
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MA242 free base is a specific dual inhibitor of MDM2 and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status[1].
- CAS number: 1049704-17-7
- Formula: C24H20ClN3O3S
- Solubility: 10 mM in DMSO
- SMILES: O=C1C(NCC2=CC=C(C=C2)Cl)=CC3=NCCC4=CN(S(=O)(C5=CC=C(C)C=C5)=O)C1=C34
- Molecular Weight: 465.95
- Applications: Cancer-programmed cell death
For research use only. Not to be used for human or animal treatment or consumption.
