KDM5A-IN-1
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KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. KDM5A-IN-1 is significantly less potent against other KDM5B enzymes (1A, 2B, 3B, 4C, 6A, 7B)[1].
- CAS number: 1905481-36-8
- Purity: 99.95
- Formula: C15H22N4O2
- Solubility: DMSO : ≥ 50 mg/mL
- SMILES: O=C(C1CC1)N[C@@H]2CCN(C(C3=CC(C(C)C)=NN3)=O)C2
- Molecular Weight: 290.36
- Applications: Cancer-programmed cell death
- -20°C, 3 years
- 4°C, 2 years (Powder)
