GRPR antagonist-1
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GRPR antagonist-1 is a potent gastrin releasing peptide receptor (GRPR) antagonist, having the cytotoxicity against certain cancer cells (IC50 of 4.97, 4.36 and 3.40 μM in PC3, Pan02 and HGC-27 cells, respectively). GRPR antagonist-1 inhibits HGC-27 cell viability by decreasing the Bcl-2 level and increasing the Bax level, causing apoptosis. Anticancer activity[1].
- Formula: C29H33F3N4O4
- Solubility: 10 mM in DMSO
- SMILES: CC(C)(OC(N1CCN(CC1)C([C@H](CC2=CNC3=C2C=CC=C3)NC(CC4=CC=C(C=C4)C(F)(F)F)=O)=O)=O)C
- Molecular Weight: 558.59
- Applications: Cancer-programmed cell death
For research use only. Not to be used for human or animal treatment or consumption.
