CBR-5884
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CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1].
- CAS number: 681159-27-3
- Purity: 99.02
- Formula: C14H12N2O4S2
- Solubility: DMSO : 50 mg/mL (ultrasonic)
- SMILES: O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC
- Molecular Weight: 336.39
- Applications: Cancer-programmed cell death
- -20°C, 3 years
- 4°C, 2 years (Powder)
