Cabozantinib (S-malate)
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Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.
- CAS number: 1140909-48-3
- Purity: 99.84
- Formula: C32H30FN3O10
- Solubility: DMSO : ≥ 23 mg/mL|H2O : 2 mg/mL (ultrasonic
- warming)
- SMILES: O=C([C@H](CC(O)=O)O)O.O=C(NC1=CC=C(C=C1)OC2=CC=NC3=CC(OC)=C(C=C23)OC)C4(CC4)C(NC5=CC=C(C=C5)F)=O
- Molecular Weight: 635.59
- Applications: Cancer-Kinase/protease
- -20°C, 3 years
- 4°C, 2 years (Powder)