Alpelisib
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Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α/p110γ/p110δ/p110β with IC50s of 5/250/290/1200 nM, respectively. Antineoplastic activity[1][2][3].
- CAS number: 1217486-61-7
- Purity: 99.95
- Formula: C19H22F3N5O2S
- Solubility: DMSO : 83.33 mg/mL (ultrasonic)
- SMILES: CC(N=C(S1)NC(N2CCC[C@H]2C(N)=O)=O)=C1C3=CC(C(C)(C(F)(F)F)C)=NC=C3
- Molecular Weight: 441.47
- Applications: Cancer-Kinase/protease
- -20°C, 3 years
- 4°C, 2 years (Powder)
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