Purified GST-tagged human Thyroid hormone receptor beta ligand binding domain

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Catalog numberN1A2-50
NamePurified GST-tagged human Thyroid hormone receptor beta ligand binding domain
Size50 μg
Price959.00EUR
SKU01014298609
SupplierVector
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Details

DescriptionPurified GST-tagged human Thyroid hormone receptor beta ligand binding domain is used mainly for ligand-binding and coregulator displacement assays
Produced inNA
ApplicationDrug discovery, Nuclear receptors, purified recombinant protein
Gene number7068
DeliveryShipped under dry ice. Additional shipping fee will be made.
StorageStore at minus 80°C
Technical filePlease inquire the latest datasheet, protocol, certificate of analysis or SDS
Tissuethyroid
Additional descriptionHormone releasing factors and releasing hormones are signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.