Bml-278 SIRT1 activator, SIRT1 activator

Information and details about product


Catalog numberSIH-349-25MG
NameBml-278 SIRT1 activator, SIRT1 activator
Size25 mg
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Stock availabilitIn StockIn Stock
CAS numberNo Available. See included datasheet
DescriptionSIRT1 activator
Molecular weight391,5 g/mol
Primary research fieldsCell Signaling, Epigenetics
Other nameN-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC24H25NO4
Purity pourcentage>98% (TLC), NMR conforms
Soluble inSoluble in 5 mg/ml DMSO
Physical appearanceOff-White Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
PubChem numberRefer to PubChem
Scientific contextA structurally novel activator of SIRT1 (EC150=1 µM). Displays selectivity over SIRT2 and 3 (EC150=25 and 50 µM respectively). Cell permeable.
Bibliography1. Mai A., et al. (2009) J. Med. Chem. 52: 5496.
Release date1-Aug-2012
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of BML-278 SIRT1 activator (SIH-349), a SIRT1 activator. CAS #: N/A. Molecular Formula: C24H25NO4. Molecular Weight: 391.5 g/mol. Chemical structure of BML-278 SIRT1 activator, a SIRT1 activator (SIH-349). CAS # N/A. Molecular Formula: C24H25NO4.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025