AG1296, PDGFR kinase inhibitor

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Catalog numberSIH-426-25MG
NameAG1296, PDGFR kinase inhibitor
Size25 mg
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Stock availabilitIn StockIn Stock
CAS number146535-11-7
DescriptionPDGFR kinase inhibitor
Molecular weight266,3 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameTyrphostin AG 1296, 6,7-Dimethoxy-3-phenylquinoxaline, 6,7-Dimethoxy-2-phenylquinoxaline
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC16H14N2O2
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO or dichloromethane
Physical appearanceOff-white to brownish solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number2049
Scientific contextAG-1296 is a potent and specific inhibitor of PDGF receptor tyrosine kinase. AG-1296 is cell-permeable.
Bibliography1. Strutz F., et al. (2001) Kidney Int. 59(2): 579–592.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AG1296 (SIH-426), a PDGFR kinase inhibitor. CAS #: 146535-11-7. Molecular Formula: C16H14N2O2. Molecular Weight: 266.3 g/mol. Chemical structure of AG1296, a PDGFR kinase inhibitor (SIH-426). CAS # 146535-11-7. Molecular Formula: C16H14N2O2.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.