AG 494, EGFR kinase inhibitor

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Catalog numberSIH-491-10MG
NameAG 494, EGFR kinase inhibitor
Size10 mg
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Stock availabilitIn StockIn Stock
CAS number133550-35-3
DescriptionEGFR kinase inhibitor
Molecular weight280,3 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameAG-494, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC16H12N2O3
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)
Physical appearanceYellow solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number5328771
Scientific contextAG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.
Bibliography1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AG 494 (SIH-491), a EGF receptor tyrosine kinase inhibitor. CAS #: 133550-35-3. Molecular Formula: C16H12N2O3. Molecular Weight: 280.3 g/mol. Chemical structure of AG 494, a EGF receptor tyrosine kinase inhibitor (SIH-491). CAS # 133550-35-3. Molecular Formula: C16H12N2O3.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.01
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.