17-GMB-APA-GA, Hsp90 inhibitor

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Catalog numberSIH-115A
Name17-GMB-APA-GA, Hsp90 inhibitor
Size1 mg
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Stock availabilitIn StockIn Stock
CAS numberNo Available. See included datasheet
DescriptionHsp90 inhibitor
Molecular weight767,9 g/mol
Primary research fieldsCancer, Heat Shock
Other namenone
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC39H53N5O11
Purity pourcentage>98%
Soluble inSoluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Physical appearancePurple Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem number57370016
Scientific contextAn analog of geldanamycin containing a maleimido moiety suitable for preparation of geldanamycin immunoconjugates (1-3). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at .
Bibliography1. Mandler R., et al. (2004) Cancer Res. 64: 1460. 2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786. 3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573.
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 17-GMB-APA-GA (SIH-115), a Hsp90 inhibitor. CAS #: N/A. Molecular Formula: C39H53N5O11. Molecular Weight: 767.9 g/mol. Chemical structure of 17-GMB-APA-GA, a Hsp90 inhibitor (SIH-115). CAS # N/A. Molecular Formula: C39H53N5O11.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.001
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.