A83 01, ALK kinase inhibitor

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Catalog numberSIH-423-5MG
NameA83 01, ALK kinase inhibitor
Size5 mg
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Stock availabilitIn StockIn Stock
CAS number909910-43-6
DescriptionALK kinase inhibitor
Molecular weight421.5 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide, A-83-01, A83-01
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC25H19N5S
Purity pourcentage≥98% (HPLC)
Soluble inSoluble to 50 mM in DMSO
Physical appearanceWhite to beige powder
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity-single exposure (Category 3), Respiratory system Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation.. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
PubChem number16218924
Scientific contextA83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase. It blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 also inhibits the transcriptional activity induced by TGFβ type I receptor ALK-5, activin type IB receptor ALK-4 and nodal type I receptor ALK-7.
Bibliography1. Li W., et al. (2009) Stem Cell 4(1): 16–19. 2. Cherukuri P., et al. (2012). PloS One. 7(11): e50066.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of A83 01 (SIH-423), a ALK kinase inhibitor. CAS #: 909910-43-6. Molecular Formula: C25H19N5S. Molecular Weight: 421.5 g/mol. Chemical structure of A83 01, a ALK kinase inhibitor (SIH-423). CAS # 909910-43-6. Molecular Formula: C25H19N5S.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.