2-APB, TRP blocker

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Catalog numberSIH-316-50MG
Name2-APB, TRP blocker
Size50 mg
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Stock availabilitIn StockIn Stock
CAS number524-95-8
DescriptionTRP blocker
Molecular weight225,1 g/mol
Primary research fieldsNeuroscience, Ion Channels, Transient Receptor Potential Channels
Other name2-Aminoethoxydiphenylborane
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC14H16BNO
Purity pourcentage>98%
Soluble inSoluble to 100 mM in DMSO and to 10 mM in ethanol
Physical appearanceWhite solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338
PubChem number1598
Scientific context2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3).
Bibliography1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329 2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328. 3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579.
Release date16-May-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 2-APB (SIH-316), a TRP blocker. CAS #: 524-95-8. Molecular Formula: C14H16BNO. Molecular Weight: 225.1 g/mol. Chemical structure of 2-APB, a TRP blocker (SIH-316). CAS # 524-95-8. Molecular Formula: C14H16BNO.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05