Bortezomib, Proteasome inhibitor

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Catalog numberSIH-328-25MG
NameBortezomib, Proteasome inhibitor
Size25 mg
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Stock availabilitIn StockIn Stock
CAS number179324-69-7
DescriptionProteasome inhibitor
Molecular weight384,2 g/mol
Primary research fieldsCancer, Apoptosis, Cancer Growth Inhibitors, Proteasome Inhibitors
Other nameB-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC19H25BN4O4
Purity pourcentage>98%
Soluble inSoluble in 50 mg/ml DMSO, 35 mg/ml Ethanol
Physical appearanceWhite Powder
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
PubChem number387447
Scientific contextPotent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.
Bibliography1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.
Release date6-Jun-2012
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Bortezomib (SIH-328), a Proteasome inhibitor. CAS #: 179324-69-7. Molecular Formula: C19H25BN4O4. Molecular Weight: 384.2 g/mol. Chemical structure of Bortezomib, a Proteasome inhibitor (SIH-328). CAS # 179324-69-7. Molecular Formula: C19H25BN4O4.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.