AICAR, Autophagy inducer

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Catalog numberSIH-402-50MG
NameAICAR, Autophagy inducer
Size50 mg
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Stock availabilitIn StockIn Stock
CAS number2627-69-2
DescriptionAutophagy inducer
Molecular weight258,2 g/mol
Primary research fieldsCancer, Autophagy
Other nameN1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
Product categorySmall Molecules
Product typeInducer
Chemical formulaC9H14N4O5
Purity pourcentage>99% (TLC); NMR (Conforms)
Soluble inSoluble to 75 mM in water and to 75 mM in DMSO.
Physical appearanceOff-white solid.
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: D2B- Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant.
PubChem number17513
Scientific contextAICAR is an adenosine analog that when phosphorylated forms 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP) which proceeds to activate adenosine monophosphate-activated protein kinase (AMPK). This process in turn stimulates glucose uptake by skeletal muscle in an insulin-dependent manner. Autophagy is initiated by the UNC-51-like kinase 1/2 complex (ULK1 and ULK2). Under basal conditions, autophagy is negatively regulated due to the phosphorylation of ULK1 at serine-757 by mTORC1. During starvation, autophagy is positively regulated by ULK1/2 when it is phosphorylated at serine-555 and serine-777 by AMPK. Therefore, the activation of AMPK by AICAR, in turn will induce autophagy.
Bibliography1. Jhun B.S., et al. (2004) Biochem Biophys Res Commun. 318(2): 372-80. 2. Huang H., et al. (2013) Autophagy. 9(2): 175-95.
Release date31-Mar-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AICAR (SIH-402), a Autophagy inducer. CAS #: 2627-69-2 . Molecular Formula: C9H14N4O5. Molecular Weight: 258.2 g/mol. Chemical structure of AICAR, a Autophagy inducer (SIH-402). CAS # 2627-69-2 . Molecular Formula: C9H14N4O5.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05