AAL 993, VEGFR inhibitor

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Information

Catalog numberSIH-424-5MG
NameAAL 993, VEGFR inhibitor
Size5 mg
Price207.00EUR
SKU01012511918
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number269390-77-4
DescriptionVEGFR inhibitor
Molecular weight371,4 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Growth Factor Receptor Inhibitors
Other name2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC20H16F3N3O
OriginSynthetic
Purity pourcentage≥98% (TLC)
Soluble inSoluble in DMSO (>25 mg/ml) or ethanol (15 mg/ml)
Physical appearancePale yellow solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number6398883
Scientific contextAAL-993 is a very potent inhibitor of VEGFR-1, VEGFR-2 and VEGFR-3, as well as PDGFR-β, c-Kit and CSF-1R at higher concentrations.
Bibliography1. Manley P.W., et al. (2004) Biochimica Biophysica Acta. 1697(1-2): 17–27. 2. Ban H.S., Uno M., & Nakamura H. (2010) Cancer Letters. 296(1): 17–26.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AAL 993 (SIH-424), a VEGFR inhibitor. CAS #: N/A. Molecular Formula: C20H16F3N3O. Molecular Weight: 371.4 g/mol. Chemical structure of AAL 993, a VEGFR inhibitor (SIH-424). CAS # N/A. Molecular Formula: C20H16F3N3O.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.