5-Azacytidine, DNA hypomethylation agent

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Information

Catalog numberSIH-345-50MG
Name5-Azacytidine, DNA hypomethylation agent
Size50 mg
Price92.00EUR
SKU01012511776
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number320-67-2
DescriptionDNA hypomethylation agent
Molecular weight244,2 g/mol
Primary research fieldsCell Signaling, Epigenetics, Cancer
Other name4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U- 18496; NSC-102816; 5-AzaC
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC8H12N4O5
OriginSynthetic
Purity pourcentage>98% (TLC); NMR (Conforms)
Soluble inSoluble in 25 mg/ml DMSO or 12 mg/ml Water
Physical appearanceWhite Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302- Harmful if swallowed H350 – May cause cancer Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/attention
PubChem number9444
Scientific contextDNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
Bibliography1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
Release date1-Aug-2012
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 5-Azacytidine (SIH-345), a DNA hypomethylation agent. CAS #: 320-67-2. Molecular Formula: C8H12N4O5. Molecular Weight: 244.2 g/mol. Chemical structure of 5-Azacytidine, a DNA hypomethylation agent (SIH-345). CAS # 320-67-2. Molecular Formula: C8H12N4O5.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05