b-AP15 (NSC-687852), DUB inhibitor

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Catalog numberSIH-339-5MG
Nameb-AP15 (NSC-687852), DUB inhibitor
Size5 mg
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Stock availabilitIn StockIn Stock
CAS number1009817-63-3
DescriptionDUB inhibitor
Molecular weight419,4 g/mol
Primary research fieldsCancer, Apoptosis
Other name(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC22H17N3O6
Purity pourcentage>98%
Soluble inSoluble in 35 mg/ml DMSO
Physical appearancePale Yellow Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
PubChem number5351435
Scientific contextAbrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Bibliography1. D’Arcy P., et al. (2011) Nature Medicine 17: 1636.
Release date6-Jun-2012
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of b-AP15 (NSC-687852) (SIH-339), a DUB inhibitor. CAS #: 1009817-63-3. Molecular Formula: C22H17N3O6. Molecular Weight: 419.4 g/mol. Chemical structure of b-AP15 (NSC-687852), a DUB inhibitor (SIH-339). CAS # 1009817-63-3. Molecular Formula: C22H17N3O6.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.