3-Methyladenine, Autophagosome inhibitor

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Catalog numberSIH-408-20MG
Name3-Methyladenine, Autophagosome inhibitor
Size20 mg
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Stock availabilitIn StockIn Stock
CAS number5142-23-4
DescriptionAutophagosome inhibitor
Molecular weight149,2 g/mol
Primary research fieldsCancer, Autophagy
Other name3-MA, 3-Methyl-3H-purin-6-amine
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC6H7N5
Purity pourcentage≥98%
Soluble inSoluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm).
Physical appearanceWhite solid.
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number1673
Scientific context3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation.
Bibliography1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6. 2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64. 3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61.
Release date31-Mar-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 3-Methyladenine (SIH-408), a Autophagosome inhibitor. CAS #: 5142-23-4. Molecular Formula: C6H7N5. Molecular Weight: 149.2 g/mol. Chemical structure of 3-Methyladenine, a Autophagosome inhibitor (SIH-408). CAS # 5142-23-4. Molecular Formula: C6H7N5.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.02
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.