Actinomycin D, Transcription inhibitor

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Catalog numberSIH-245-50MG
NameActinomycin D, Transcription inhibitor
Size50 mg
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Stock availabilitIn StockIn Stock
CAS number50-76-0
DescriptionTranscription inhibitor
Molecular weight1255,43 g/mol
Primary research fieldsCancer, Apoptosis
Other name2-Amino-N,N'-bis(6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC62H86N12O16
Purity pourcentage>98%
Soluble inSoluble to 50 mM in DMSO
Physical appearanceWhite Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Very Toxic. May be fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R26/27/28 - Very Toxic by inhalation, in contact with skin and if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin R40 - Limited evidence of a carcinogenic effect R62 - Possible risk of impaired fertility Hazard Phrases: H300 – Fatal if swallowed Precautionary Phrases: P264 –P301 + P310
PubChem number2019
Scientific contextThe actinomycins are a class of polypeptide antibiotics. Actinomycin D inhibits transcription by binding DNA at the transcription initiation complex and preventing elongation by RNA polymerase (1). Actinomycin D has been used as a chemotherapy drug (2), and an antibiotic.
Bibliography1. Sobell H. (1985) Proc Natl Acad Sci USA. 82(16): 5328-31. 2. Turan T., et al. (2006) Int J Gynecol Cancer. 16(3): 1432-1438.
Release date16-May-2011
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Actinomycin D (SIH-245), a Transcription inhibitor. CAS #: 50-76-0. Molecular Formula: C62H86N12O16. Molecular Weight: 1255.43 g/mol. Chemical structure of Actinomycin D, a Transcription inhibitor (SIH-245). CAS # 50-76-0. Molecular Formula: C62H86N12O16.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.05
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.The activation of transcription factor subunits is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerases. Transcription factors, unites and elongations can be RNA and DNA nucleic acids, base pairs of nucleotides . Converting from DNA to RNA is made by enzymatic reactions. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. Transcriptions are key functions in signal transduction pathways. Signaling ligand binding transcription factors play an important role in transduction cascades.