AG 879, NGFR kinase inhibitor

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Catalog numberSIH-429-5MG
NameAG 879, NGFR kinase inhibitor
Size5 mg
Price140.00EUR
SKU01012511928
Supplierstressma
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Details

Stock availabilitIn StockIn Stock
CAS number148741-30-4
DescriptionNGFR kinase inhibitor
Molecular weight316,5 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameTyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC18H24N2OS
OriginSynthetic
Purity pourcentage≥99% (TLC)
Soluble inSoluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)
Physical appearanceYellow solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number5487525
Scientific contextAG879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2.
Bibliography1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol. Chemical structure of AG 879, a NGFR kinase inhibitor (SIH-429). CAS # 148741-30-4. Molecular Formula: C18H24N2OS.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.