BIX-01294, HMT inhibitor

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Catalog numberSIH-347-25MG
NameBIX-01294, HMT inhibitor
Size25 mg
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Stock availabilitIn StockIn Stock
CAS number935693-62-2
DescriptionHMT inhibitor
Molecular weight600,02 g/mol
Primary research fieldsCell Signaling, Epigenetics, Cancer
Other name2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC28H38N6O2*3HCl
Purity pourcentage>98%
Soluble inMay be dissolved in DMSO (100 mM) or Water (100 mM)
Physical appearanceCream solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
PubChem number25150857
Scientific contextG9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
Bibliography1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.
Release date11-Apr-2013
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of BIX-01294 (SIH-347), a Histone methyltransferase inhibitor. CAS #: 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl. Molecular Weight: 600.02 g/mol. Chemical structure of BIX-01294, a Histone methyltransferase inhibitor (SIH-347). CAS # 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.