BRL-50481, PDE7 inhibitor

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Catalog numberSIH-374-10MG
NameBRL-50481, PDE7 inhibitor
Size10 mg
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Stock availabilitIn StockIn Stock
CAS number433695-36-4
DescriptionPDE7 inhibitor
Molecular weight244,26 g/mol
Primary research fieldsNeuroscience
Other nameN,N,2-Trimethyl-5-nitro-benzenesulfonamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC9H12N2O4S
Purity pourcentage>98% (TLC); NMR (Conforms)
Soluble inMay be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml)
Physical appearanceCream solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem number2921148
Scientific contextBRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor. In the presence of BRL-50481 the activity of hrPDE7A1 was inhibited against the phosphodiesterase (PDE3) and (PDE4) (1). Studies have suggested a potential role of BRL-50481 in the treatment of osteoporosis (2).
Bibliography1. Smith J., et al. (2004) Molecular Biology Pharmacology. 66(6): 1679-89. 2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.
Release date4-Apr-2013
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of BRL-50481 (SIH-374), a PDE7 inhibitor. CAS #: 433695-36-4. Molecular Formula: C9H12N2O4S. Molecular Weight: 244.26 g/mol. Chemical structure of BRL-50481, a PDE7 inhibitor (SIH-374). CAS # 433695-36-4. Molecular Formula: C9H12N2O4S.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.01
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.