115-7C, Hsp70 Activator

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Catalog numberSIH-123-25MG
Name115-7C, Hsp70 Activator
Size25 mg
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Stock availabilitIn StockIn Stock
CAS numberNo Available. See included datasheet
DescriptionHsp70 Activator
Molecular weight477,34 g/mol
Primary research fieldsCancer, Heat Shock
Other name4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2
Product categorySmall Molecules
Product typeActivator
Chemical formulaC23H22Cl2N2O5
Purity pourcentage>98%
Soluble inSoluble in DMSO (20 mg/ml)
Physical appearanceWhite Solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
PubChem numberRefer to PubChem
Scientific context115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
Bibliography1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486
Release date30-Aug-2016
PubMed number27611863
Tested applicationsIn vitro activation
Tested reactivityCercariae
Representative figure legendChemical structure of 115-7C (SIH-123), a Hsp70 Activator. Molecular Formula: C₂₃H₂₂Cl₂N₂O₅. Molecular Weight: 477.34 g/mol. Chemical structure of 115-7C, a Hsp70 Activator (SIH-123). Molecular Formula: C₂₃H₂₂Cl₂N₂O₅.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.025