Bafilomycin A1, Autophagy inhibitor

Information and details about product


Catalog numberSIH-391-500UG
NameBafilomycin A1, Autophagy inhibitor
Size500 µg
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Stock availabilitIn StockIn Stock
CAS number88899-55-2
DescriptionAutophagy inhibitor
Molecular weight622,84 g/mol
Primary research fieldsCancer, Autophagy
Other name(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC35H58O9
Purity pourcentage≥95%
Soluble inSoluble in 100% ethanol, methanol or DMSO.
Physical appearanceWhite powder to colorless film.
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: D2B- Toxic Material Causing Other Toxic Effects Irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant.
PubChem number6436223
Scientific contextBafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus. It selectively inhibits vacuolar-type H+-ATPases, allowing it to be used to differentiate between different types of ATPases. Bafilomycin also acts to inhibit autophagy by either blocking autophagosome-lysosome fusion, or by blocking lysosomal degradation.
Bibliography1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212. 2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16. 3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42.
Release date31-Mar-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol. Chemical structure of Bafilomycin A1, a Autophagy inhibitor (SIH-391). CAS # 88899-55-2. Molecular Formula: C35H58O9.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.0005
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.