Axitinib, VEGFR kinase inhibitor

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Catalog numberSIH-494-10MG
NameAxitinib, VEGFR kinase inhibitor
Size10 mg
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Stock availabilitIn StockIn Stock
CAS number319460-85-0
DescriptionVEGFR kinase inhibitor
Molecular weight386,5 g/mol
Primary research fieldsCell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other nameAG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide, N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide
Product categorySmall Molecules
Product typeInhibitor
Chemical formulaC22H18N4OS
Purity pourcentage≥98% (HPLC)
Soluble inSoluble to 25 mM in DMSO
Physical appearanceWhite to tan powder
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Acute toxicity, Oral (Category 4), H302 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H410 Very toxic to aquatic life with long lasting effects Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P330 Rinse mouth. P391 Collect spillage. P501 Dispose of contents/ container to an approved waste disposal plant.
PubChem number6450551
Scientific contextAxitinib is a potent and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. It has also been shown to inhibit PDGFR-β and c-Kit.
Bibliography1. Hu-Lowe D.D., et al. (2008) Clin. Cancer Res: J. Am. Ass. Cancer Res. 14(22): 7272–7283.
Release date1-Oct-2014
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of Axitinib (SIH-494), a VEGFR kinase inhibitor. CAS #: 319460-85-0. Molecular Formula: C22H18N4OS. Molecular Weight: 386.5 g/mol. Chemical structure of Axitinib, a VEGFR kinase inhibitor (SIH-494). CAS # 319460-85-0. Molecular Formula: C22H18N4OS.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.01
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.