6-Formylindolo(3,2-b)carbazole, Ah receptor ligand

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Catalog numberSIH-383-100UG
Name6-Formylindolo(3,2-b)carbazole, Ah receptor ligand
Size100 µg
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Stock availabilitIn StockIn Stock
CAS number172922-91-7
DescriptionAh receptor ligand
Molecular weight284,3 g/mol
Primary research fieldsCell Signaling
Other nameIndolo[3,2-b]carbazole-6-carbaldehyde, FICZ
Product categorySmall Molecules
Product typeLigand
Chemical formulaC19H12N2O
Purity pourcentage>95%
Soluble inSoluble in DMSO (10 mg/ml)
Physical appearanceYellow solid
Storage recommendations-20ºC
Shipping recommendationsShipped Ambient
Safety informationClassification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
PubChem number22245026
Scientific contextA tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7x10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.
Bibliography1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55. 2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855. 3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
Release date17-Jul-2013
PubMed numberRefer to PubMed
Tested applicationsTo be tested
Tested reactivityTo be tested
Representative figure legendChemical structure of 6-Formylindolo(3,2-b)carbazole (SIH-383), a Ah receptor ligand. CAS #: 172922-91-7. Molecular Formula: C19H12N2O. Molecular Weight: 284.3 g/mol. Chemical structure of 6-Formylindolo(3,2-b)carbazole, a Ah receptor ligand (SIH-383). CAS # 172922-91-7. Molecular Formula: C19H12N2O.
Warning informationNon-hazardous
Country of productionCanada
Total weight (kg)0.25
Net weight (g)0.0001
Additional descriptionFAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.